Formulation and Evaluation of Liquisolid Compacts of Carvedilol P.Sandhya

The purpose of this study is to develop a novel liquisolid technique to enhance the dissolution rate of poorly water soluble drug Carvedilol, a BCS class II drug, which is a β-blocker, by using different excipients. The main components of a liquisolid system are a non volatile solvent, carrier and coating materials and a disintegrant. Liquisolid system refers to the formulations that are formed by conversion of liquid drugs, drug suspensions or drug solution in non-volatile solvents into dry, non adherent, free flowing and compressible powder mixture by blending with suitable carrier and coating materials. Hence the dissolution step, a prerequisite for drug absorption, is by passed and better bioavailability of poorly soluble drug is achieved. Liquisolid tablets of carvedilol are prepared by using PEG, PG, glycerine as non volatile liquid vehicles and Avicel PH 101 and 102, Aerosil as carrier and coating materials respectively. Optimized formulation containing 20% drug in PEG 400, with Avicel 101 as carrier and Aerosil as coating material has shown 98.4% drug release within 20 min which is better than marketed product (CARCA 12.5mg, Intas). The DSC and X-RD studies are performed to investigate the physicochemical properties of formulation and drug excipient interactions. The results are found to be satisfactory.